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IL37 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - IL37 Antibody AP50940
    Western blot analysis of lysate from human brain tissue lysate, using IL37 Antibody(A1-1822).A1-1822 was diluted at 1:500. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody.Lysate at 20ug.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9NZH6
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 24,22,20,17 KDa
Additional Information
Gene ID 27178
Other Names Interleukin-37, FIL1 zeta, IL-1X, Interleukin-1 family member 7, IL-1F7, Interleukin-1 homolog 4, IL-1H, IL-1H4, Interleukin-1 zeta, IL-1 zeta, Interleukin-1-related protein, IL-1RP1, Interleukin-23, IL-37, IL37, FIL1Z, IL1F7, IL1H4, IL1RP1
Dilution WB~~ 1:500
Format Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 55% glycerol
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name IL37
Synonyms FIL1Z, IL1F7, IL1H4, IL1RP1
Function Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Cellular Location Cytoplasm, cytosol Nucleus. Secreted Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647). Only the CASP1- cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730)
Tissue Location In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node Isoform D and isoform E were found only in testis and bone marrow Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.
Research Areas
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Background

Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.

References

Kumar S.,et al.J. Biol. Chem. 275:10308-10314(2000).
Manoj P.P.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Pan G.,et al.Cytokine 13:1-7(2001).
Smith D.E.,et al.J. Biol. Chem. 275:1169-1175(2000).
Taylor S.L.,et al.Genomics 79:726-733(2002).

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$ 295.00
Cat# AP50940
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
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