|Calculated MW||24,22,20,17 KDa|
|Other Names||Interleukin-37, FIL1 zeta, IL-1X, Interleukin-1 family member 7, IL-1F7, Interleukin-1 homolog 4, IL-1H, IL-1H4, Interleukin-1 zeta, IL-1 zeta, Interleukin-1-related protein, IL-1RP1, Interleukin-23, IL-37, IL37, FIL1Z, IL1F7, IL1H4, IL1RP1|
|Format||Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 55% glycerol|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Synonyms||FIL1Z, IL1F7, IL1H4, IL1RP1|
|Function||Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.|
|Cellular Location||Cytoplasm, cytosol Nucleus. Secreted Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647). Only the CASP1- cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730)|
|Tissue Location||In general, low constitutive expression, if any, in healthy tissues; high expression in inflammatory counterparts, including in synovial tissues from individuals with active rheumatoid arthritis. Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node Isoform D and isoform E were found only in testis and bone marrow Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.|
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Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation.
Kumar S.,et al.J. Biol. Chem. 275:10308-10314(2000).
Manoj P.P.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Pan G.,et al.Cytokine 13:1-7(2001).
Smith D.E.,et al.J. Biol. Chem. 275:1169-1175(2000).
Taylor S.L.,et al.Genomics 79:726-733(2002).
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