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G6PD Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P11413 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 59257 Da |
| Antigen Region | 297-326 aa |
| Gene ID | 2539 |
|---|---|
| Other Names | Glucose-6-phosphate 1-dehydrogenase, G6PD, G6PD |
| Target/Specificity | This G6PD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 297-326 amino acids from the Central region of human G6PD. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | G6PD Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | G6PD |
|---|---|
| Function | Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. |
| Cellular Location | Cytoplasm, cytosol. Membrane; Peripheral membrane protein |
| Tissue Location | Isoform Long is found in lymphoblasts, granulocytes and sperm |
Provided below are standard protocols that you may find useful for product applications.
Background
G6PD encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia.
References
Louicharoen, C., et al. Science 326(5959):1546-1549(2009)
Zhong, D.N., et al. Zhongguo Dang Dai Er Ke Za Zhi 11(12):970-972(2009)
Tiono, A.B., et al. Am. J. Trop. Med. Hyg. 81(6):969-978(2009)
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