- CITATIONS: 1
|Application ||WB, IHC-P, E|
|Other Accession||Q9N008, Q96FE5, Q50L44|
|Calculated MW||69101 Da|
|Antigen Region||575-603 aa|
|Other Names||Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, Lingo1, Lern1, Lrrn6a|
|Target/Specificity||This LINGO-1(LRRN6A) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-603 amino acids from the C-terminal region of human LINGO-1(LRRN6A).|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||LINGO-1(LRRN6A)-S596 (C-term) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei.|
Provided below are standard protocols that you may find useful for product applications.
LINGO-1 is functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. LINGO-1 is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.
Mandai, K., et al. Neuron 63(5):614-627(2009)
Homma, S., et al. Gene Expr. Patterns 9(1):1-26(2009)
Pernet, V., et al. J. Neurosci. 28(29):7435-7444(2008)
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