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LINGO-1(LRRN6A)-S596 (C-term) Antibody

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - LINGO-1(LRRN6A)-S596 (C-term) Antibody AP5096d
    All lanes : Anti-LINGO-1(LRRN6A)-S596 (C-term) Antibody at 1:1000-1:2000 dilution Lane 1: Mouse brain lysate Lane 2: Mouse cerebellum lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 69 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • IHC-P - LINGO-1(LRRN6A)-S596 (C-term) Antibody AP5096d
    LINGO-1(LRRN6A)-S596 (C-term) Antibody (Cat. #AP5096d) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the LINGO-1(LRRN6A)-S596 (C-term) Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
  • SPECIFICATION
  • CITATIONS: 1
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9D1T0
Other Accession Q9N008, Q96FE5, Q50L44
Reactivity Human, Mouse
Predicted Chicken, Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 69101 Da
Antigen Region 575-603 aa
Additional Information
Gene ID 235402
Other Names Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, Lingo1, Lern1, Lrrn6a
Target/Specificity This LINGO-1(LRRN6A) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-603 amino acids from the C-terminal region of human LINGO-1(LRRN6A).
Dilution WB~~1:1000-1:2000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsLINGO-1(LRRN6A)-S596 (C-term) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Lingo1
Synonyms Lern1, Lrrn6a
Function Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (By similarity). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Highly specific expression in the central nervous system. Predominant expression in neocortex, amygdala, hippocampus, thalamus and entorhinal cortex, with lower levels in cerebellum and basal nuclei.
Research Areas
Citations ( 0 )

Background

LINGO-1 is functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. LINGO-1 is also an important negative regulator of oligodentrocyte differentiation and axonal myelination.

References

Mandai, K., et al. Neuron 63(5):614-627(2009)
Homma, S., et al. Gene Expr. Patterns 9(1):1-26(2009)
Pernet, V., et al. J. Neurosci. 28(29):7435-7444(2008)

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$ 295.00
$ 99.00
Cat# AP5096d
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Quantity:
(40 western blots)
Availability: In Stock
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