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ARRDC1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ARRDC1 Antibody AP50997
    Anti-ARRDC1 Antibodyat 1:1000 dilution + mouse stomach lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 46 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q8N5I2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 46 KDa
Antigen Region 151 - 210 aa
Additional Information
Gene ID 92714
Other Names Arrestin domain-containing protein 1, ARRDC1
Target/Specificity KLH conjugated synthetic peptide derived from human ARRDC1
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ARRDC1 (HGNC:28633)
Function Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940).
Cellular Location Cell membrane. Note=Also found in extracellular vesicles different from exosomes.
Research Areas
Citations (0)
citation

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References

Humphray S.J.,et al.Nature 429:369-374(2004).

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$ 350.00
Cat# AP50997
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