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Atrophin-1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Atrophin-1 Antibody AP51002
    Anti-Atrophin-1 Antibody at 1:1000 dilution + HeLa whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 125 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P54259
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 150 KDa
Additional Information
Gene ID 1822
Other Names Atrophin-1, Dentatorubral-pallidoluysian atrophy protein, ATN1, D12S755E, DRPLA
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ATN1
Synonyms D12S755E, DRPLA
Function Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Asn (polyQ) repeats.
Cellular Location Nucleus. Cytoplasm, perinuclear region. Cell junction. Note=Shuttles between nucleus and cytoplasm. Colocalizes with FAT1 in the perinuclear area, at cell- cell junctions and leading edges of cells (By similarity) Colocalizes with MTG8 in discrete nuclear dots. Proteolytic fragment F1 appears to remain in nucleus. Fragment F2 is exported into the cytoplasm. Fragment F2 from mutant sequences with longer poly-Asn (polyQ) tracts are additionally located to the cytoplasmic membrane and to certain organelles.
Tissue Location Widely expressed in various tissues including heart, lung, kidney, ovary, testis, prostate, placenta, skeletal Low levels in the liver, thymus and leukocytes. In the adult brain, broadly expressed in amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus, and thalamus. High levels in fetal tissues, especially brain.
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Background

Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Asn (polyQ) repeats.

References

Nagafuchi S.,et al.Nat. Genet. 8:177-182(1994).
Onodera O.,et al.Am. J. Hum. Genet. 57:1050-1060(1995).
Margolis R.L.,et al.Brain Res. Mol. Brain Res. 36:219-226(1996).
Ansari-Lari M.A.,et al.Genome Res. 7:268-280(1997).
Yanagisawa H.,et al.Hum. Mol. Genet. 5:373-379(1996).

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$ 295.00
Cat# AP51002
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
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