|Application ||WB, IF, FC, E|
|Calculated MW||43884 Da|
|Antigen Region||45-72 aa|
|Other Names||Adiponectin receptor protein 2, Progestin and adipoQ receptor family member II, ADIPOR2, PAQR2|
|Target/Specificity||This ADIPOR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-72 amino acids from the Central region of human ADIPOR2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADIPOR2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.|
|Cellular Location||Membrane; Multi-pass membrane protein Note=Localized to the cell membrane and intracellular organelles|
|Tissue Location||Highly expressed in skeletal muscle, liver and placenta. Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung|
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Provided below are standard protocols that you may find useful for product applications.
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.
Ferguson, J.F., et al. Am. J. Clin. Nutr. 91(3):794-801(2010) Halvatsiotis, I., et al. Cardiovasc Diabetol 9, 10 (2010) Yoshihara, K., et al. J Reprod Med 54 (11-12), 669-674 (2009)
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