ADIPOR2 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 2
- PROTOCOLS
- BACKGROUND
Application
| IF, WB, FC, E |
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Primary Accession | Q86V24 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 43884 Da |
Antigen Region | 45-72 aa |
Gene ID | 79602 |
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Other Names | Adiponectin receptor protein 2, Progestin and adipoQ receptor family member II, ADIPOR2, PAQR2 |
Target/Specificity | This ADIPOR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-72 amino acids from the Central region of human ADIPOR2. |
Dilution | IF~~1:10~50 WB~~1:1000 FC~~1:25 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ADIPOR2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ADIPOR2 (HGNC:24041) |
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Function | Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:12802337, PubMed:25855295). Required for normal body fat and glucose homeostasis. ADIPOQ-binding activates a signaling cascade that leads to increased PPARA activity, and ultimately to increased fatty acid oxidation and glucose uptake. Has intermediate affinity for globular and full-length adiponectin. Required for normal revascularization after chronic ischemia caused by severing of blood vessels (By similarity). |
Cellular Location | Cell membrane; Multi-pass membrane protein Note=Localized to the cell membrane and intracellular organelles |
Tissue Location | Ubiquitous (PubMed:16044242). Highly expressed in skeletal muscle, liver and placenta (PubMed:12802337). Weakly expressed in brain, heart, colon, spleen, kidney, thymus, small intestine, peripheral blood leukocytes and lung (PubMed:12802337) |
Provided below are standard protocols that you may find useful for product applications.
Background
The adiponectin receptors, ADIPOR1 (MIM 607945) and ADIPOR2, serve as receptors for globular and full-length adiponectin (MIM 605441) and mediate increased AMPK (see MIM 602739) and PPAR-alpha (PPARA; MIM 170998) ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.
References
Ferguson, J.F., et al. Am. J. Clin. Nutr. 91(3):794-801(2010) Halvatsiotis, I., et al. Cardiovasc Diabetol 9, 10 (2010) Yoshihara, K., et al. J Reprod Med 54 (11-12), 669-674 (2009)
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