|Calculated MW||18 KDa|
|Other Names||Cyclin-dependent kinase 4 inhibitor C, Cyclin-dependent kinase 6 inhibitor, p18-INK4c, p18-INK6, CDKN2C, CDKN6|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.|
|Tissue Location||Highest levels found in skeletal muscle. Also found in pancreas and heart|
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Provided below are standard protocols that you may find useful for product applications.
Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Guan K.-L.,et al.Genes Dev. 8:2939-2952(1994).
Blais A.,et al.Biochem. Biophys. Res. Commun. 247:146-153(1998).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Venkataramani R.,et al.Nat. Struct. Biol. 5:74-81(1998).
Li J.,et al.Biochemistry 38:2930-2940(1999).
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