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CLCN4 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P51793 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 85 KDa |
| Antigen Region | 201 - 260 aa |
| Gene ID | 1183 |
|---|---|
| Other Names | H(+)/Cl(-) exchange transporter 4, Chloride channel protein 4, ClC-4, Chloride transporter ClC-4, CLCN4 |
| Target/Specificity | KLH conjugated synthetic peptide derived from human CLCN4 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CLCN4 |
|---|---|
| Function | Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:18063579, PubMed:28972156, PubMed:23647072, PubMed:27550844, PubMed:25644381). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874). |
| Cellular Location | Early endosome membrane {ECO:0000250|UniProtKB:P51794}; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Localizes to late endosome membrane, lysosome membrane and recycling endosome membrane in the presence of CLCN3 |
| Tissue Location | Abundant in skeletal muscle and also detectable in brain and heart |
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Provided below are standard protocols that you may find useful for product applications.
Background
Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons.
References
van Slegtenhorst M.A.,et al.Hum. Mol. Genet. 3:547-552(1994).
Kawasaki M.,et al.Am. J. Physiol. 277:C948-C954(1999).
Rae J.L.,et al.Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
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