|Reactivity||Human, Mouse, Rat|
|Calculated MW||57 KDa|
|Other Names||Cytochrome P450 2J2, Arachidonic acid epoxygenase, CYPIIJ2, CYP2J2|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.|
|Cellular Location||Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein|
|Tissue Location||Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney|
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Provided below are standard protocols that you may find useful for product applications.
This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.
Wu S.,et al.J. Biol. Chem. 271:3460-3468(1996).
Wu S.,et al.Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
King L.M.,et al.Mol. Pharmacol. 61:840-852(2002).
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