|Application ||WB, IHC-P, FC, E|
|Calculated MW||168903 Da|
|Antigen Region||375-404 aa|
|Other Names||Zinc finger FYVE domain-containing protein 16, Endofin, Endosome-associated FYVE domain protein, ZFYVE16, KIAA0305|
|Target/Specificity||This ZFYVE16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-404 amino acids from the N-terminal region of human ZFYVE16.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZFYVE16 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in regulating membrane trafficking in the endosomal pathway. Overexpression induces endosome aggregation. Required to target TOM1 to endosomes.|
|Cellular Location||Cytoplasm. Early endosome membrane; Peripheral membrane protein. Note=Localized to early endosomes. Membrane-associated, probably via its association with phosphatidylinositol 3-phosphate (PI3P)|
|Tissue Location||Widely expressed. Highly expressed in kidney, placenta and lung. Expressed at intermediate level in heart, brain, skeletal muscle, spleen and liver. Weakly expressed in colon, thymus and peripheral blood lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
The ZFYVE16 gene encodes endofin, an endosomal protein implicated in regulating membrane trafficking. It is characterized by the presence of a phosphatidylinositol 3-phosphate-binding FYVE domain positioned in the middle of the molecule.
Toy, W., et al. Cell. Signal. 22(3):437-446(2010) Chen, Y., et al. Proteomics 7(14):2384-2397(2007) Shi, W., et al. J. Cell. Sci. 120 (PT 7), 1216-1224 (2007)
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