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COVID19
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CD49e LC Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CD49e LC Antibody AP51289
    Anti-CD49e LC Antibodyat 1:1000 dilution + A549 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 115 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P08648
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 18 KDa
Antigen Region 851 - 910 aa
Additional Information
Gene ID 3678
Other Names Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5, FNRA
Target/Specificity KLH conjugated synthetic peptide derived from human CD49e LC
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name ITGA5 (HGNC:6141)
Synonyms FNRA
Function Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion
Tissue Location Expressed in placenta (at protein level).
Research Areas
Citations (0)
citation

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Background

Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

References

Argraves W.S.,et al.J. Cell Biol. 105:1183-1190(1987).
Birkenmeier T.M.,et al.J. Biol. Chem. 266:20544-20549(1991).
Fitzgerald L.A.,et al.Biochemistry 26:8158-8165(1987).
Argraves W.S.,et al.J. Biol. Chem. 261:12922-12924(1986).
Takada Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:3239-3243(1987).

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$ 350.00
Cat# AP51289
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Availability: 2 weeks
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