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Monoamine Oxidase A Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Monoamine Oxidase A Antibody AP51327
    Anti-Monoamine Oxidase A Antibodyat 1:1000 dilution + human heart lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 60 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P21397
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 61 KDa
Antigen Region 291 - 350 aa
Additional Information
Gene ID 4128
Other Names Amine oxidase [flavin-containing] A, Monoamine oxidase type A, MAO-A, MAOA
Target/Specificity KLH conjugated synthetic peptide derived from human Monoamine Oxidase A
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name MAOA (HGNC:6833)
Function Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:20493079, PubMed:8316221, PubMed:18391214, PubMed:24169519). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).
Cellular Location Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21396}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:P21396}; Cytoplasmic side {ECO:0000250|UniProtKB:P21396}
Tissue Location Heart, liver, duodenum, blood vessels and kidney.
Research Areas
Citations (0)
citation

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Background

Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.

References

Hsu Y.-P.P.,et al.J. Neurochem. 51:1321-1324(1988).
Bach A.W.J.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:4934-4938(1988).
Chen Z.-Y.,et al.Nucleic Acids Res. 19:4537-4541(1991).
Grimsby J.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:3637-3641(1991).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 350.00
Cat# AP51327
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Availability: 2 weeks
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