|Application ||WB, IHC-P, FC, E|
|Other Accession||Q6MG81, O35450|
|Calculated MW||38176 Da|
|Antigen Region||264-292 aa|
|Other Names||FK506-binding protein-like, WAF-1/CIP1 stabilizing protein 39, WISp39, FKBPL, DIR1, NG7|
|Target/Specificity||This FKBPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-292 amino acids from the C-terminal region of human FKBPL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FKBPL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.|
|Tissue Location||Ubiquitously expressed with higher levels in testis.|
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Provided below are standard protocols that you may find useful for product applications.
FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.
McKeen, H.D., et al. Cancer Res. 70(3):1090-1100(2010)
Sunnotel, O., et al. Reprod. Biol. Endocrinol. 8, 22 (2010)
Barcellos, L.F., et al. PLoS Genet. 5 (10), E1000696 (2009)
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