|Application ||WB, IHC-P, FC, E|
|Other Accession||P0C606, Q9DA08, Q5ZL38|
|Predicted||Chicken, Mouse, Rat|
|Calculated MW||33238 Da|
|Antigen Region||179-208 aa|
|Other Names||SAGA-associated factor 29 homolog, Coiled-coil domain-containing protein 101, CCDC101, SGF29|
|Target/Specificity||This SGF29 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 179-208 amino acids from the C-terminal region of human SGF29.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SGF29 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.|
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Provided below are standard protocols that you may find useful for product applications.
CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases.
Imielinski, M., et al. Nat. Genet. 41(12):1335-1340(2009)
Wang, Y.L., et al. J. Biol. Chem. 283(49):33808-33815(2008)
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