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PGRMC2 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - PGRMC2 Antibody AP51427
    Anti-PGRMC2 Antibodyat 1:1000 dilution + NIH/3T3 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 24 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O15173
Reactivity Human, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 24 KDa
Antigen Region 161 - 220 aa
Additional Information
Gene ID 10424
Other Names Membrane-associated progesterone receptor component 2, Progesterone membrane-binding protein, Steroid receptor protein DG6, PGRMC2, DG6, PMBP
Target/Specificity KLH conjugated synthetic peptide derived from human PGRMC2
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name PGRMC2 (HGNC:16089)
Function Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity).
Cellular Location Membrane; Single- pass membrane protein. Nucleus envelope. Endoplasmic reticulum. Secreted
Tissue Location Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Detected in urine (at protein level) (PubMed:37453717).
Research Areas
Citations (0)
citation

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Background

Receptor for steroids (Potential).

References

Gerdes D.,et al.Biol. Chem. 379:907-911(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Olsen J.V.,et al.Cell 127:635-648(2006).
Daub H.,et al.Mol. Cell 31:438-448(2008).
Dephoure N.,et al.Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).

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$ 350.00
Cat# AP51427
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