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RRAD Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P55042 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33 KDa |
| Antigen Region | 31 - 90 aa |
| Gene ID | 6236 |
|---|---|
| Other Names | GTP-binding protein RAD, RAD1, Ras associated with diabetes, RRAD, RAD |
| Target/Specificity | KLH conjugated synthetic peptide derived from human RRAD |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | RRAD |
|---|---|
| Synonyms | RAD |
| Function | May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (By similarity). May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L- type Ca(2+) currents (By similarity). Regulates voltage-dependent L- type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin- dependent kinase II (CaMKII) pathway (PubMed:18056528). Inhibits phosphorylation and activation of CAMK2D (PubMed:18056528). |
| Cellular Location | Cell membrane. |
| Tissue Location | Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans. |
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Provided below are standard protocols that you may find useful for product applications.
Background
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.
References
Reynet C.,et al.Science 262:1441-1444(1993).
Moyers J.S.,et al.J. Biol. Chem. 272:11832-11839(1997).
Chang L.,et al.Circulation 116:2976-2983(2007).
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