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ARALAR1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O75746 |
| Reactivity | Human, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 75 KDa |
| Antigen Region | 371 - 430 aa |
| Gene ID | 8604 |
|---|---|
| Other Names | Calcium-binding mitochondrial carrier protein Aralar1, Mitochondrial aspartate glutamate carrier 1, Solute carrier family 25 member 12, SLC25A12, ARALAR1 |
| Target/Specificity | KLH conjugated synthetic peptide derived from human ARALAR1 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SLC25A12 (HGNC:10982) |
|---|---|
| Function | Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:11566871, PubMed:19641205, PubMed:24515575). Also mediates the uptake of L-cysteinesulfinate by mitochondria in exchange of L- glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:11566871). |
| Cellular Location | Mitochondrion inner membrane; Multi-pass membrane protein |
| Tissue Location | Expressed predominantly in the heart and skeletal muscle, weakly in brain and kidney. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.
References
Del Arco A.,et al.J. Biol. Chem. 273:23327-23334(1998).
Palmieri L.,et al.EMBO J. 20:5060-5069(2001).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Kobayashi K.,et al.Nat. Genet. 22:159-163(1999).
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