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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   Topoisomerase 2 beta Antibody   

Topoisomerase 2 beta Antibody

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Topoisomerase 2 beta Antibody AP51578
    Anti-Topoisomerase 2 beta Antibodyat 1:1000 dilution + MOLT-4 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 183 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q02880
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 183 KDa
Additional Information
Gene ID 7155
Other Names DNA topoisomerase 2-beta, DNA topoisomerase II, beta isozyme, TOP2B
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name TOP2B
Function Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.
Cellular Location Cytoplasm. Nucleus, nucleolus.
Research Areas
Citations (0)

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Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene.


Jenkins J.R.,et al.Nucleic Acids Res. 20:5587-5592(1992).
Austin C.A.,et al.Biochim. Biophys. Acta 1172:283-291(1993).
Chung T.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:9431-9435(1989).
Sng J.H.,et al.Biochim. Biophys. Acta 1444:395-406(1999).
Austin C.A.,et al.FEBS Lett. 266:115-117(1990).

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$ 295.00
Cat# AP51578
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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