|Calculated MW||183 KDa|
|Other Names||DNA topoisomerase 2-beta, DNA topoisomerase II, beta isozyme, TOP2B|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|
|Cellular Location||Cytoplasm. Nucleus, nucleolus.|
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Provided below are standard protocols that you may find useful for product applications.
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene.
Jenkins J.R.,et al.Nucleic Acids Res. 20:5587-5592(1992).
Austin C.A.,et al.Biochim. Biophys. Acta 1172:283-291(1993).
Chung T.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:9431-9435(1989).
Sng J.H.,et al.Biochim. Biophys. Acta 1444:395-406(1999).
Austin C.A.,et al.FEBS Lett. 266:115-117(1990).
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