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Topoisomerase 2 beta Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q02880 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 183 KDa |
| Antigen Region | 11 - 70 aa |
| Gene ID | 7155 |
|---|---|
| Other Names | DNA topoisomerase 2-beta, DNA topoisomerase II, beta isozyme, TOP2B |
| Target/Specificity | KLH conjugated synthetic peptide derived from human Topoisomerase 2 beta |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TOP2B |
|---|---|
| Function | Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. |
| Cellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus |
| Tissue Location | Expressed in the tonsil, spleen, lymph node, thymus, skin, pancreas, testis, colon, kidney, liver, brain and lung (PubMed:9155056). Also found in breast, colon and lung carcinomas, Hodgkin's disease, large-cell non-Hodgkin's lymphoma, lymphocytic lymphomas and seminomas (PubMed:9155056). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene.
References
Jenkins J.R.,et al.Nucleic Acids Res. 20:5587-5592(1992).
Austin C.A.,et al.Biochim. Biophys. Acta 1172:283-291(1993).
Chung T.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 86:9431-9435(1989).
Sng J.H.,et al.Biochim. Biophys. Acta 1444:395-406(1999).
Austin C.A.,et al.FEBS Lett. 266:115-117(1990).
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