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Tyrosinase Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Tyrosinase Antibody AP51594
    All lanes : Anti-Tyrosinase Antibody at 1:1000 dilution Lane 1: Hela whole cell lysates Lane 2: Jurkat whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 60 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P14679
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 60.4 KDa
Antigen Region 461 - 520 aa
Additional Information
Gene ID 7299
Other Names Tyrosinase, LB24-AB, Monophenol monooxygenase, SK29-AB, Tumor rejection antigen AB, TYR
Target/Specificity KLH conjugated synthetic peptide derived from human Tyrosinase
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name TYR (HGNC:12442)
Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4- dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA- quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (PubMed:28661582).
Cellular Location Melanosome membrane; Single-pass type I membrane protein. Melanosome {ECO:0000250|UniProtKB:P11344}. Note=Proper trafficking to melanosome is regulated by SGSM2, ANKRD27, RAB9A, RAB32 and RAB38 {ECO:0000250|UniProtKB:P11344}
Research Areas
Citations (0)
citation

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Background

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.

References

Giebel L.B.,et al.Genomics 9:435-445(1991).
Kwon B.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:7473-7477(1987).
Kwon B.S.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:6352-6352(1988).
Bouchard B.,et al.J. Exp. Med. 169:2029-2042(1989).
Chintamaneni C.D.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:5272-5276(1991).

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$ 350.00
Cat# AP51594
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