VGF Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB |
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Primary Accession | O15240 |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 90 KDa |
Antigen Region | 431 - 490 aa |
Gene ID | 7425 |
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Other Names | Neurosecretory protein VGF, Neuroendocrine regulatory peptide-1, NERP-1, Neuroendocrine regulatory peptide-2, NERP-2, Antimicrobial peptide VGF[554-577], VGF |
Target/Specificity | KLH conjugated synthetic peptide derived from human VGF |
Dilution | WB~~ 1:1000 |
Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
Storage | Store at -20 °C.Stable for 12 months from date of receipt |
Name | VGF |
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Function | [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). |
Cellular Location | [Neurosecretory protein VGF]: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus |
Tissue Location | Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system (By similarity). Antimicrobial peptide VGF[554-577]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.
References
Canu N.,et al.Genomics 45:443-446(1997).
Hillier L.W.,et al.Nature 424:157-164(2003).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Sasaki K.,et al.Mol. Cell. Proteomics 12:700-709(2013).
Toshinai K.,et al.Cell. Mol. Life Sci. 66:1939-1945(2009).
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