|Application ||WB, E|
|Calculated MW||53904 Da|
|Antigen Region||396-423 aa|
|Other Names||Ectonucleoside triphosphate diphosphohydrolase 8, E-NTPDase 8, NTPDase 8, NTPDase8, ENTPD8|
|Target/Specificity||This ENTPD8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 396-423 amino acids from the C-terminal region of human ENTPD8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ENTPD8 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
ENTPD8 is canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. It is ectonucleoside NTPDases catalyze the hydrolyzis of gamma-and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. ENTPD8 has activity toward ATP, ADP, UTP and UDP, but not toward AMP.
Munkonda, M.N., et al. Biochem. Pharmacol. 74(10):1524-1534(2007)
Fausther, M., et al. Am. J. Physiol. Gastrointest. Liver Physiol. 292 (3), G785-G795 (2007)
Knowles, A.F., et al. Biochemistry 45(23):7323-7333(2006)
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