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ADA2A Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O75478 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 51 KDa |
| Antigen Region | 211 - 270 aa |
| Gene ID | 6871 |
|---|---|
| Other Names | Transcriptional adapter 2-alpha, Transcriptional adapter 2-like, ADA2-like protein, TADA2A, TADA2L |
| Target/Specificity | KLH conjugated synthetic peptide derived from human ADA2A |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | TADA2A |
|---|---|
| Synonyms | TADA2L |
| Function | Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (PubMed:22644376). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (PubMed:22644376). |
| Cellular Location | Nucleus. Chromosome {ECO:0000250|UniProtKB:Q8CHV6} |
| Tissue Location | Expressed in all tissues, but most abundantly in testis |
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Provided below are standard protocols that you may find useful for product applications.
Background
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.
References
Candau R.,et al.Mol. Cell. Biol. 16:593-602(1996).
Huang X.,et al.Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Zody M.C.,et al.Nature 440:1045-1049(2006).
Ogryzko V.V.,et al.Cell 94:35-44(1998).
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