|Application ||WB, IHC-P, FC, E|
|Calculated MW||31385 Da|
|Antigen Region||59-87 aa|
|Other Names||Palmitoyltransferase ZDHHC21, Zinc finger DHHC domain-containing protein 21, DHHC-21, ZDHHC21|
|Target/Specificity||This ZDHHC21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-87 amino acids from the N-terminal region of human ZDHHC21.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZDHHC21 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein. Golgi apparatus|
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Provided below are standard protocols that you may find useful for product applications.
The function of this protein has not been specifically defined.
Mill, P., et al. PLoS Genet. 5 (11), E1000748 (2009)
Le Clerc, S., et al. J. Infect. Dis. 200(8):1194-1201(2009)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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