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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > ZDHHC21 Antibody (N-term)
ZDHHC21 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, FC, IHC-P, E |
|---|---|
| Primary Accession | Q8IVQ6 |
| Other Accession | A2VDT6 |
| Reactivity | Human, Mouse |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31385 Da |
| Antigen Region | 59-87 aa |
| Gene ID | 340481 |
|---|---|
| Other Names | Palmitoyltransferase ZDHHC21, Zinc finger DHHC domain-containing protein 21, DHHC-21, ZDHHC21 |
| Target/Specificity | This ZDHHC21 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-87 amino acids from the N-terminal region of human ZDHHC21. |
| Dilution | WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ZDHHC21 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ZDHHC21 (HGNC:20750) |
|---|---|
| Function | Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates (PubMed:22031296). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane (PubMed:22031296). This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (PubMed:22031296). Palmitoylates FYN, regulates its localization in hair follicles and plays a key role in epidermal homeostasis and hair follicle differentiation. Through the palmitoylation of PLCB1 and the regulation of PLCB1 downstream signaling may indirectly regulate the function of the endothelial barrier and the adhesion of leukocytes to the endothelium. Has also a palmitoyltransferase activity toward ADRA1D, positively regulating its activity and expression and may thereby play a role in vascular contraction. May also palmitoylate eNOS and LCK (By similarity). |
| Cellular Location | Golgi apparatus membrane; Multi-pass membrane protein. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q9D270}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Widely expressed.. |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The function of this protein has not been specifically defined.
References
Mill, P., et al. PLoS Genet. 5 (11), E1000748 (2009)
Le Clerc, S., et al. J. Infect. Dis. 200(8):1194-1201(2009)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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$ 365.00
$ 140.00
Cat# AP5172A
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