|Application ||WB, IHC-P, FC, E|
|Other Accession||Q6ZPT1, Q2T9Z7|
|Calculated MW||69429 Da|
|Antigen Region||299-326 aa|
|Other Names||Kelch-like protein 9, KLHL9, KIAA1354|
|Target/Specificity||This KLHL9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 299-326 amino acids from the Central region of human KLHL9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KLHL9 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.|
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KLHL9 is substrate-specific adapter for a CUL3-based E3 ubiquitin-protein ligase complex. Within this complex, it controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
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