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CHAC1 Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CHAC1 Antibody AP51743
    All lanes : Anti-CHAC1 Antibody at 1:1000 dilution Lane 1: Hela whole cell lysates Lane 2: PC-12 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 29 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession Q9BUX1
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 24 KDa
Additional Information
Gene ID 79094
Other Names Glutathione-specific gamma-glutamylcyclotransferase 1, Gamma-GCG 1, 232-, Blocks Notch protein, Botch, Cation transport regulator-like protein 1, CHAC1 {ECO:0000303|PubMed:19109178, ECO:0000312|HGNC:HGNC:28680}
Dilution WB~~ 1:1000
Format 0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%
StorageStore at -20 °C.Stable for 12 months from date of receipt
Protein Information
Name CHAC1 {ECO:0000303|PubMed:19109178, ECO:0000312|HGNC:HGNC:28680}
Function Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).
Cellular Location Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8R3J5}
Research Areas
Citations (0)

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Background

Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade.

References

Zody M.C.,et al.Nature 440:671-675(2006).
Zheng J.M.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Mungrue I.N.,et al.J. Immunol. 182:466-476(2009).
Chi Z.,et al.Dev. Cell 22:707-720(2012).

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$ 295.00
Cat# AP51743
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
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