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CHAC1 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9BUX1 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24 KDa |
| Antigen Region | 11 - 70 aa |
| Gene ID | 79094 |
|---|---|
| Other Names | Glutathione-specific gamma-glutamylcyclotransferase 1, Gamma-GCG 1, 232-, Blocks Notch protein, Botch, Cation transport regulator-like protein 1, CHAC1 {ECO:0000303|PubMed:19109178, ECO:0000312|HGNC:HGNC:28680} |
| Target/Specificity | KLH conjugated synthetic peptide derived from human CHAC1 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | CHAC1 {ECO:0000303|PubMed:19109178, ECO:0000312|HGNC:HGNC:28680} |
|---|---|
| Function | Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides (PubMed:27913623). Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366). |
| Cellular Location | Cytoplasm, cytosol. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8R3J5} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade.
References
Zody M.C.,et al.Nature 440:671-675(2006).
Zheng J.M.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Mungrue I.N.,et al.J. Immunol. 182:466-476(2009).
Chi Z.,et al.Dev. Cell 22:707-720(2012).
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