|Application ||WB, E|
|Calculated MW||92688 Da|
|Other Names||Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase, MAP3K11 (HGNC:6850)|
|Target/Specificity||This MAP3K11 antibody is generated from rabbits immunized with MAP3K11 recombinant protein.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAP3K11 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Location is cell cycle dependent|
|Tissue Location||Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.|
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Provided below are standard protocols that you may find useful for product applications.
MAP3K11 is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42.
Rangasamy, V., et al. Cancer Res. 70(4):1731-1740(2010)
Velho, S., et al. Hum. Mol. Genet. 19(4):697-706(2010)
Cole, E.T., et al. Biochim. Biophys. Acta 1793(12):1811-1818(2009)
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