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Pyruvate Carboxylase Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | P11498 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 130 KDa |
| Antigen Region | 341 - 400 aa |
| Gene ID | 5091 |
|---|---|
| Other Names | Pyruvate carboxylase, mitochondrial, Pyruvic carboxylase, PCB, PC |
| Target/Specificity | KLH conjugated synthetic peptide derived from human Pyruvate Carboxylase |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | PC (HGNC:8636) |
|---|---|
| Function | Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate. |
| Cellular Location | Mitochondrion matrix |
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Provided below are standard protocols that you may find useful for product applications.
Background
Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.
References
Wexler I.D.,et al.Biochim. Biophys. Acta 1227:46-52(1994).
Mackay N.,et al.Biochem. Biophys. Res. Commun. 202:1009-1014(1994).
Walker M.E.,et al.Submitted (JUL-1995) to the EMBL/GenBank/DDBJ databases.
Lamhonwah A.-M.,et al.Arch. Biochem. Biophys. 254:631-636(1987).
Freytag S.O.,et al.J. Biol. Chem. 259:12831-12837(1984).
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