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ATXN2L Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - ATXN2L Antibody (C-term) AP5183b
    Western blot analysis of ATXN2L Antibody (C-term) (Cat. #AP5183b) in HepG2 cell line lysates (35ug/lane).ATXN2L (arrow) was detected using the purified Pab.
  • FC - ATXN2L Antibody (C-term) AP5183b
    ATXN2L Antibody (C-term) (Cat. #AP5183b) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession Q8WWM7
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 113374 Da
Antigen Region 1021-1048 aa
Additional Information
Gene ID 11273
Other Names Ataxin-2-like protein, Ataxin-2 domain protein, Ataxin-2-related protein, ATXN2L, A2D, A2LG, A2LP, A2RP
Target/Specificity This ATXN2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1021-1048 amino acids from the C-terminal region of human ATXN2L.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsATXN2L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ATXN2L
Synonyms A2D, A2LG, A2LP, A2RP
Function Involved in the regulation of stress granule and P-body formation.
Cellular Location Membrane; Peripheral membrane protein Cytoplasm. Nucleus speckle. Cytoplasmic granule. Note=Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791) Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791)
Tissue Location Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells
Citations (0)

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Background

ATXN2L encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders.

References

Imielinski, M., et al. Nat. Genet. 41(12):1335-1340(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Nonhoff, U., et al. Mol. Biol. Cell 18(4):1385-1396(2007)

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$ 295.00
$ 99.00
Cat# AP5183b
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Quantity:
(40 western blots)
Availability: In Stock
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