|Application ||WB, FC, E|
|Calculated MW||113374 Da|
|Antigen Region||1021-1048 aa|
|Other Names||Ataxin-2-like protein, Ataxin-2 domain protein, Ataxin-2-related protein, ATXN2L, A2D, A2LG, A2LP, A2RP|
|Target/Specificity||This ATXN2L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1021-1048 amino acids from the C-terminal region of human ATXN2L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ATXN2L Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||A2D, A2LG, A2LP, A2RP|
|Function||Involved in the regulation of stress granule and P-body formation.|
|Cellular Location||Membrane; Peripheral membrane protein Cytoplasm. Nucleus speckle. Cytoplasmic granule. Note=Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791) Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791)|
|Tissue Location||Expressed at high levels in thymus, lymph node, spleen, fetal kidney and adult testis. Constitutively associated with MPL and EPOR in hematopoietic cells|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ATXN2L encodes an ataxin type 2 related protein of unknown function. This protein is a member of the spinocerebellar ataxia (SCAs) family, which is associated with a complex group of neurodegenerative disorders.
Imielinski, M., et al. Nat. Genet. 41(12):1335-1340(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Nonhoff, U., et al. Mol. Biol. Cell 18(4):1385-1396(2007)
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