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SCN2B Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | O60939 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 24 KDa |
| Antigen Region | 51 - 110 aa |
| Gene ID | 6327 |
|---|---|
| Other Names | Sodium channel subunit beta-2, SCN2B |
| Target/Specificity | KLH conjugated synthetic peptide derived from human SCN2B |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | SCN2B |
|---|---|
| Function | Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity). |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Brain specific. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity).
References
Eubanks J.,et al.NeuroReport 8:2775-2779(1997).
Bolino A.,et al.Eur. J. Hum. Genet. 6:629-634(1998).
Cruz J.S.,et al.Science 284:711-711(1999).
Isom L.L.,et al.Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
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