|Calculated MW||45 KDa|
|Other Names||Caspase-1, CASP-1, Interleukin-1 beta convertase, IL-1BC, Interleukin-1 beta-converting enzyme, ICE, IL-1 beta-converting enzyme, p45, Caspase-1 subunit p20, Caspase-1 subunit p10, CASP1, IL1BC, IL1BCE|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.|
|Tissue Location||Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.|
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Provided below are standard protocols that you may find useful for product applications.
Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis.
Thornberry N.A.,et al.Nature 356:768-774(1992).
Cerretti D.P.,et al.Science 256:97-100(1992).
Alnemri E.S.,et al.J. Biol. Chem. 270:4312-4317(1995).
Totoki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
Taylor T.D.,et al.Nature 440:497-500(2006).
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