|Reactivity||Human, Mouse, Rat|
|Calculated MW||70 KDa|
|Antigen Region||421 - 480 aa|
|Other Names||Sphingomyelin phosphodiesterase, Acid sphingomyelinase, aSMase, SMPD1, ASM|
|Target/Specificity||KLH conjugated synthetic peptide derived from human Acid Sphingomyelinase|
|Format||0.01M PBS, pH 7.2, 0.1% Sodium azide, Glycerol 50%|
|Storage||Store at -20 °C.Stable for 12 months from date of receipt|
|Function||Converts sphingomyelin to ceramide (PubMed:1840600, PubMed:18815062, PubMed:27659707, PubMed:25920558). Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol.|
|Cellular Location||Lysosome. Secreted|
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Provided below are standard protocols that you may find useful for product applications.
Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.
Schuchman E.H.,et al.J. Biol. Chem. 266:8531-8539(1991).
Newrzella D.,et al.Biol. Chem. Hoppe-Seyler 373:1233-1238(1992).
Schuchman E.H.,et al.Genomics 12:197-205(1992).
Ida H.,et al.J. Biochem. 114:15-20(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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