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FHL2 Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q14192 |
| Reactivity | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 32 KDa |
| Antigen Region | 71 - 130 aa |
| Gene ID | 2274 |
|---|---|
| Other Names | Four and a half LIM domains protein 2, FHL-2, LIM domain protein DRAL, Skeletal muscle LIM-protein 3, SLIM-3, FHL2, DRAL, SLIM3 |
| Target/Specificity | KLH conjugated synthetic peptide derived from human FHL2 |
| Dilution | WB~~ 1:1000 |
| Format | 0.01M PBS, pH 7.2, 0.09% (W/V) Sodium azide, Glycerol 50% |
| Storage | Store at -20 °C.Stable for 12 months from date of receipt |
| Name | FHL2 |
|---|---|
| Synonyms | DRAL, SLIM3 |
| Function | May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). |
| Cellular Location | Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:O35115} |
| Tissue Location | Expressed in skeletal muscle and heart. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.
References
Genini M.,et al.DNA Cell Biol. 16:433-442(1997).
Chan K.K.,et al.Gene 210:345-350(1998).
Tanahashi H.,et al.Hum. Mol. Genet. 9:2281-2289(2000).
Qian Z.,et al.Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
Morgan M.J.,et al.Biochem. Biophys. Res. Commun. 225:632-638(1996).
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