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>   home   >   Products   >   Primary Antibodies   >   Rabbit Anti-ATF4/CREB-2 Polyclonal Antibody   

Rabbit Anti-ATF4/CREB-2 Polyclonal Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Rabbit Anti-ATF4/CREB-2 Polyclonal Antibody AP52146
    Lane 1:Mouse embryo lysate Lane 2:Mouse eye lysate probed with Rabbit Anti-ATF4/CREB-2 Polyclonal Antibody, Unconjugated (AP52146) at 1:300 overnight at 4˚C. Followed by conjugation to secondary antibody at 1:5000 for 90 min at 37˚C.
  • IHC-P - Rabbit Anti-ATF4/CREB-2 Polyclonal Antibody AP52146
    Formalin-fixed and paraffin embedded mouse brain labeled with Anti-ATF4/CREB-2 Polyclonal Antibody, Unconjugated (AP52146) at 1:200 followed by conjugation to the secondary antibody and DAB staining
  • IHC-P - Rabbit Anti-ATF4/CREB-2 Polyclonal Antibody AP52146
    Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-ATF4/CREB-2 Polyclonal Antibody, Unconjugated AP52146 at 1:200 followed by conjugation to the secondary antibody and DAB staining
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, IF
Primary Accession P18848
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 38590 Da
Additional Information
Gene ID 468
Other Names CREB2; TXREB; CREB-2; TAXREB67; Cyclic AMP-dependent transcription factor ATF-4; cAMP-dependent transcription factor ATF-4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; Tax-responsive enhancer element-binding protein 67; ATF4
Dilution WB~~1:100~1:500
IHC-P~~1:100~1:500
Format0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
StorageStore at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃.
Protein Information
Name ATF4
Synonyms CREB2, TXREB
Function Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to endoplasmic reticulum (ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors (PubMed:26086088).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q9ES19}. Cell membrane {ECO:0000250|UniProtKB:Q9ES19}. Nucleus Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with GABBR1 in hippocampal neuron dendritic membranes (By similarity) Colocalizes with NEK6 at the centrosome (PubMed:20873783) {ECO:0000250|UniProtKB:Q9ES19, ECO:0000269|PubMed:20873783}
Citations (0)

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Background

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.

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$ 295.00
Cat# AP52146
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
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