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ENPP6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, E |
|---|---|
| Primary Accession | Q6UWR7 |
| Other Accession | B0BND0, Q58D68, Q8BGN3 |
| Reactivity | Human, Mouse |
| Predicted | Pig, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50241 Da |
| Antigen Region | 170-197 aa |
| Gene ID | 133121 |
|---|---|
| Other Names | Ectonucleotide pyrophosphatase/phosphodiesterase family member 6, E-NPP 6, NPP-6, 314-, Choline-specific glycerophosphodiester phosphodiesterase, Glycerophosphocholine cholinephosphodiesterase, GPC-Cpde, ENPP6 |
| Target/Specificity | This ENPP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-197 amino acids from the Central region of human ENPP6. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | ENPP6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ENPP6 (HGNC:23409) |
|---|---|
| Function | Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:15788404). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet- activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity). |
| Cellular Location | Cell membrane; Lipid-anchor, GPI-anchor. Note=A small amount of the protein may be found in the extracellular milieu |
| Tissue Location | Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
ENPP6 is choline-specific glycerophosphodiester phosphodiesterase. This protein hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate.
References
Sakagami, H., et al. J. Biol. Chem. 280(24):23084-23093(2005)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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