|Application ||WB, IF, FC, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||29274 Da|
|Other Names||IGM; IMD3; TRAP; gp39; CD154; CD4L; HIGM1; T-BAM; TNFSF5; hCD4L; CD4 ligand; CD4-L; T-cell antigen Gp39; TNF-related activation protein; Tumor necrosis factor ligand superfamily member 5; CD4LG|
|Format||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce|
|Storage||Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃.|
|Synonyms||CD40L, TNFSF5, TRAP|
|Function||Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein|
|Tissue Location||Specifically expressed on activated CD4+ T- lymphocytes|
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Provided below are standard protocols that you may find useful for product applications.
Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching. Release of soluble CD4L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.
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