|Application ||WB, FC, E|
|Calculated MW||45886 Da|
|Antigen Region||379-407 aa|
|Other Names||F-box/LRR-repeat protein 14, F-box and leucine-rich repeat protein 14, FBXL14, FBL14|
|Target/Specificity||This FBXL14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 379-407 amino acids from the C-terminal region of human FBXL14.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXL14 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-recognition component of some SCF (SKP1-CUL1- F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1.|
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Provided below are standard protocols that you may find useful for product applications.
FBXL14 is members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains.
Vinas-Castells, R., et al. J. Biol. Chem. 285(6):3794-3805(2010)
Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)
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