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Rabbit Anti-Aquaporin 4 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, IF |
|---|---|
| Primary Accession | P55088 |
| Reactivity | Human, Mouse, Rat, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34436 Da |
| Gene ID | 11829 |
|---|---|
| Other Names | WCH4; Aquaporin-4; AQP-4; Mercurial-insensitive water channel; MIWC; Aqp4 |
| Dilution | WB~~1:100~1:500 IHC-P~~1:100~1:500 FC~~1:20~1:100 |
| Format | 0.01M TBS(pH7.4), 0.09% (W/V) sodium azide and 50% Glyce |
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃. |
| Name | Aqp4 |
|---|---|
| Function | Forms a water-specific channel (PubMed:8660998, PubMed:9276712, PubMed:18286643). Plays an important role in brain water homeostasis and in glymphatic solute transport (PubMed:22896675, PubMed:27751903, PubMed:30561329, PubMed:30557661). Required for a normal rate of water exchange across the blood brain interface (PubMed:30557661). Required for normal levels of cerebrospinal fluid influx into the brain cortex and parenchyma along paravascular spaces that surround penetrating arteries, and for normal drainage of interstitial fluid along paravenous drainage pathways. Thereby, it is required for normal clearance of solutes from the brain interstitial fluid, including soluble beta-amyloid peptides derived from APP (PubMed:22896675, PubMed:27751903, PubMed:30561329). Plays a redundant role in urinary water homeostasis and urinary concentrating ability (PubMed:9276712). |
| Cellular Location | Cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Basolateral cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Endosome membrane {ECO:0000250|UniProtKB:P47863}. Cell membrane, sarcolemma; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Cell projection. Note=Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane (By similarity). Detected on brain astrocyte processes and astrocyte endfeet close to capillaries (PubMed:22896675). {ECO:0000250|UniProtKB:P47863, ECO:0000269|PubMed:22896675} |
| Tissue Location | Detected in brain cortex, especially around cortical blood vessels, and subjacent to pia, with lower levels in parenchymal membranes (PubMed:27751903). Detected in ependymal and astroglial cells in brain (PubMed:8660998, PubMed:9276712, PubMed:22896675, PubMed:27751903). Detected in supporting Hensen's cells, inner sulcus cells and Claudius cells in the inner ear (PubMed:11406631). Detected in skeletal muscle (PubMed:29055082) Detected in gastric parietal cells (PubMed:10915655). Detected in principal cells in collecting ducts in kidney medulla (at protein level) (PubMed:9276712, PubMed:16641094). Detected in brain, heart and skeletal muscle (PubMed:8660998). |
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
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Discontinued
Cat# AP52226
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