|Application ||WB, IHC-P, E|
|Other Accession||Q91Z49, Q17QU6|
|Calculated MW||35818 Da|
|Antigen Region||26-54 aa|
|Other Names||UAP56-interacting factor, Forty-two-three domain-containing protein 1, Protein 40-2-3, FYTTD1, UIF|
|Target/Specificity||This FYTD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-54 amino acids from the N-terminal region of human FYTD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FYTD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4.|
|Cellular Location||Nucleus, nucleoplasm. Nucleus speckle|
|Tissue Location||Expressed in a wide variety of cancer types.|
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Provided below are standard protocols that you may find useful for product applications.
FYTD1 required for mRNA export from the nucleus to the cytoplasm. This protein acts as an adapter that uses the BAT1/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. FYTD1 associates with spliced and unspliced mRNAs simultaneously with THOC4.
Hautbergue, G.M., et al. Curr. Biol. 19(22):1918-1924(2009)
Pope, S.N., et al. J. Steroid Biochem. Mol. Biol. 94 (1-3), 203-208 (2005)
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