Rabbit Anti-Lymphocyte Activation Gene 3 Polyclonal Antibody
Purified Rabbit Polyclonal Antibody (Pab)
|Application ||WB, IF, FC, ICC, IHC-P|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||57988 Da|
|Other Names||CD223; Lymphocyte activation gene 3 protein; LAG-3; Lag3|
|Format||0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce|
|Storage||Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 ℃.|
|Function||Involved in lymphocyte activation. Binds to HLA class-II antigens (By similarity).|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Lymphocyte-activation protein 3 (LAG-3), also known as CD223, belongs to the immunoglobulin superfamily and contains 4 extracellular Ig-like domains. LAG-3 binds to HLA class-II antigens and is involved in lymphocyte activation. It is found on the cell surface of activated NK and T-lymphocytes. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG-3 to CD4.
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