|Application ||WB, IHC-P, E|
|Calculated MW||23565 Da|
|Antigen Region||96-123 aa|
|Other Names||Geminin, GMNN|
|Target/Specificity||This GMNN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the Central region of human GMNN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GMNN Antibody (Center Y111) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.|
|Cellular Location||Cytoplasm. Nucleus. Note=Mainly cytoplasmic but can be relocalized to the nucleus|
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Provided below are standard protocols that you may find useful for product applications.
GMNN inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
De Marco, V., et al. Proc. Natl. Acad. Sci. U.S.A. 106(47):19807-19812(2009)
Zhu, W., et al. Cancer Res. 69(11):4870-4877(2009)
Lu, F., et al. Biol. Cell 101(5):273-285(2009)
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