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>   home   >   Products   >   Primary Antibodies   >   Cancer   >   GMNN Antibody (Center Y111)   

GMNN Antibody (Center Y111)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - GMNN Antibody (Center Y111) AP5227c
    Western blot analysis of GMNN Antibody (Center Y111) (Cat. #AP5227c) in HepG2 cell line lysates (35ug/lane).GMNN (arrow) was detected using the purified Pab.
  • IHC-P - GMNN Antibody (Center Y111) AP5227c
    GMNN Antibody (Center Y111) (Cat. #AP5227c) IHC analysis in formalin fixed and paraffin embedded lung tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GMNN Antibody (Center Y111) for immunohistochemistry. Clinical relevance has not been evaluated.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession O75496
Other Accession O88513
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 23565 Da
Antigen Region 96-123 aa
Additional Information
Gene ID 51053
Other Names Geminin, GMNN
Target/Specificity This GMNN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the Central region of human GMNN.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGMNN Antibody (Center Y111) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GMNN
Function Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.
Cellular Location Cytoplasm. Nucleus. Note=Mainly cytoplasmic but can be relocalized to the nucleus
Research Areas
Citations (0)

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Background

GMNN inhibits DNA replication by preventing the incorporation of MCM complex into prereplication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle.

References

De Marco, V., et al. Proc. Natl. Acad. Sci. U.S.A. 106(47):19807-19812(2009)
Zhu, W., et al. Cancer Res. 69(11):4870-4877(2009)
Lu, F., et al. Biol. Cell 101(5):273-285(2009)

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$ 295.00
$ 99.00
Cat# AP5227c
Size:
Quantity:
(40 western blots)
Availability: In Stock
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