|Application ||WB, IHC-P, E|
|Calculated MW||42400 Da|
|Antigen Region||288-316 aa|
|Other Names||HAUS augmin-like complex subunit 4, HAUS4, C14orf94|
|Target/Specificity||This HAUS4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 288-316 amino acids from the C-terminal region of human HAUS4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HAUS4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle Note=Localizes to interphase centrosomes and to mitotic spindle microtubules|
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Provided below are standard protocols that you may find useful for product applications.
HAUS4 encodes a subunit of the centrosome complex termed the human augmin complex. The encoded protein localizes to the spindle microtubules and may play a role in mitotic spindle assembly and maintenance of centrosome integrity during cell division.
Lawo, S., et al. Curr. Biol. 19(10):816-826(2009)
Uehara, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(17):6998-7003(2009)
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