|Application ||WB, IHC-P, FC, E|
|Calculated MW||17684 Da|
|Antigen Region||35-61 aa|
|Other Names||Interleukin-36 alpha, FIL1 epsilon, Interleukin-1 epsilon, IL-1 epsilon, Interleukin-1 family member 6, IL-1F6, IL36A, FIL1E, IL1E, IL1F6|
|Target/Specificity||This IL1F6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-61 amino acids from the Central region of human IL1F6.|
|Precautions||IL1F6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FIL1E, IL1E, IL1F6|
|Function||Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of proinflammatory cytokines such as TNF-alpha, IL-8 and IL-6. In cultured monocytes upregulates expression of IL-1A, IL-1B and IL-6. In myeloid dendritic cells involved in cell maturation by upregulating surface expression of CD83, CD86 and HLA-DR. In monocyte-derived dendritic cells facilitates dendritic cell maturation and drives T-cell proliferation. May play a role in proinflammatory effects in the lung.|
|Tissue Location||Expressed in immune system and fetal brain, but not in other tissues tested or in multiple hematopoietic cell lines. Predominantly expressed in skin keratinocytes but not in fibroblasts, endothelial cells or melanocytes. Increased in lesional psoriasis skin.|
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Provided below are standard protocols that you may find useful for product applications.
The function of this protein has not been specifically defined.
Kim, T.J., et al. J. Rheumatol. 35(8):1603-1608(2008)
Blumberg, H., et al. J. Exp. Med. 204(11):2603-2614(2007)
Zhan, X., et al. Anal. Biochem. 354(2):279-289(2006)
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