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CCR5 (Phospho-Ser349) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CCR5 (Phospho-Ser349) Antibody AP52366
    Western blot analysis of extracts from HeLa cells treated with PMA (125ng/ml, 30mins), using CCR5 (Phospho-Ser349) antibody.
  • WB - CCR5 (Phospho-Ser349) Antibody AP52366
    Western blot analysis of extracts from A549 cells (Lane 2), using CCR5 (Phospho-Ser349) Antibody. The lane on the left is treated with synthesized peptide.
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession P51681
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Calculated MW 40524 Da
Additional Information
Gene ID 1234
Other Names C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CCR5, CHEMR13, HIV-1 fusion coreceptor, CD195, CCR5, CMKBR5
Dilution WB~~1:1000
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name CCR5
Synonyms CMKBR5
Function Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung
Research Areas
Citations (0)

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Background

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates.

References

Samson M.,et al.Biochemistry 35:3362-3367(1996).
Raport C.J.,et al.J. Biol. Chem. 271:17161-17166(1996).
Combadiere C.,et al.J. Leukoc. Biol. 60:147-152(1996).
Kuhmann S.E.,et al.J. Virol. 71:8642-8656(1997).
Zhang L.,et al.AIDS Res. Hum. Retroviruses 13:1357-1366(1997).

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$ 295.00
Cat# AP52366
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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