|Application ||IHC-P, E|
|Calculated MW||88605 Da|
|Antigen Region||294-322 aa|
|Other Names||AP-5 complex subunit zeta-1, Adaptor-related protein complex 5 zeta subunit, Zeta5, AP5Z1, KIAA0415, SPG48|
|Target/Specificity||This K0415 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-322 amino acids from the Central region of human K0415.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||K0415 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair.|
|Cellular Location||Cytoplasm. Nucleus. Note=By SDS-PAGE, 2 isoforms have been observed, the shorter seems to be predominantly nuclear and the longer is mostly cytoplasmic|
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Provided below are standard protocols that you may find useful for product applications.
The function of this protein has not been specifically defined.
Hillier, L.W., et al. Nature 424(6945):157-164(2003)
Scherer, S.W., et al. Science 300(5620):767-772(2003)
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