|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||61652 Da|
|Other Names||Wiskott-Aldrich syndrome protein family member 1, WASP family protein member 1, Protein WAVE-1, Verprolin homology domain-containing protein 1, WASF1, KIAA0269, SCAR1, WAVE1|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Synonyms||KIAA0269, SCAR1, WAVE1|
|Function||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|
|Cellular Location||Cytoplasm, cytoskeleton. Cell junction, synapse. Note=Dot-like pattern in the cytoplasm Concentrated in Rac-regulated membrane-ruffling areas|
|Tissue Location||Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood|
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Provided below are standard protocols that you may find useful for product applications.
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
Bear J.E.,et al.J. Cell Biol. 142:1325-1335(1998).
Nagase T.,et al.DNA Res. 3:321-329(1996).
Mungall A.J.,et al.Nature 425:805-811(2003).
Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Machesky L.M.,et al.Curr. Biol. 8:1347-1356(1998).
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