|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||202167 Da|
|Other Names||Integrin beta-4, GP150, CD104, ITGB4|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Function||Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein. Cell membrane; Lipid-anchor. Cell junction, hemidesmosome. Note=Colocalizes with DST at the leading edge of migrating keratinocytes|
|Tissue Location||Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoform beta-4D is also expressed in colon and placenta. Isoform beta-4E is also expressed in epidermis, lung, duodenum, heart, spleen and stomach|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility.
Suzuki S.,et al.EMBO J. 9:757-763(1990).
Hogervorst F.,et al.EMBO J. 9:765-770(1990).
Tamura R.N.,et al.J. Cell Biol. 111:1593-1604(1990).
Pulkkinen L.,et al.Lab. Invest. 76:823-833(1997).
Iacovacci S.,et al.Mamm. Genome 8:448-450(1997).
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