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IRS-1 (Phospho-Ser312) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - IRS-1 (Phospho-Ser312) Antibody AP52464
    Western blot analysis of extracts from HepG2 cells, using IRS-1 (Phospho-Ser312) antibody.
  • WB - IRS-1 (Phospho-Ser312) Antibody AP52464
    Western blot analysis of extracts from HepG2 cells (Lane 2), using IRS-1 (Phospho-Ser312) Antibody. The lane on the left is treated with synthesized peptide.
  • IF - IRS-1 (Phospho-Ser312) Antibody AP52464
    Immunofluorescence analysis of HeLa cells, using IRS-1 (Phospho-Ser312) antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IF
Primary Accession P35568
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 131591 Da
Additional Information
Gene ID 3667
Other Names Insulin receptor substrate 1, IRS-1, IRS1
Dilution WB~~1:1000
IF~~1:100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name IRS1
Function May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).
Research Areas
Citations (0)

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Background

May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit (By similarity).

References

Araki E.,et al.Diabetes 42:1041-1054(1993).
Nishiyama M.,et al.Biochem. Biophys. Res. Commun. 183:280-285(1992).
Smith L.K.,et al.Biochem. Biophys. Res. Commun. 196:767-772(1993).
Craparo A.,et al.J. Biol. Chem. 270:15639-15643(1995).
He W.,et al.J. Biol. Chem. 270:23258-23262(1995).

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$ 295.00
Cat# AP52464
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
Bulk Size
Seasonal Special on Bulk Order
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