|Application ||WB, IHC-P, FC, E|
|Other Accession||Q4PS85, Q9JK37|
|Calculated MW||31745 Da|
|Antigen Region||40-69 aa|
|Other Names||Myozenin-1, Calsarcin-2, Filamin-, actinin- and telethonin-binding protein, Protein FATZ, MYOZ1 (HGNC:13752)|
|Target/Specificity||This MYOZ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the Central region of human MYOZ1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MYOZ1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis.|
|Cellular Location||Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle|
|Tissue Location||Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. This protein plays an important role in the modulation of calcineurin signaling, may play a role in myofibrillogenesis.
Aurino, S., et al. Acta Myol 27, 90-97 (2008) Posch, M.G., et al. Mol. Genet. Metab. 91(2):207-208(2007) Arola, A.M., et al. Mol. Genet. Metab. 90(4):435-440(2007)
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