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MYOZ1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | Q9NP98 |
| Other Accession | Q4PS85, Q9JK37 |
| Reactivity | Human, Mouse |
| Predicted | Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31745 Da |
| Antigen Region | 40-69 aa |
| Gene ID | 58529 |
|---|---|
| Other Names | Myozenin-1, Calsarcin-2, Filamin-, actinin- and telethonin-binding protein, Protein FATZ, MYOZ1 (HGNC:13752) |
| Target/Specificity | This MYOZ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the Central region of human MYOZ1. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | MYOZ1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MYOZ1 (HGNC:13752) |
|---|---|
| Function | Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. |
| Cellular Location | Nucleus. Cell projection, pseudopodium. Note=Localized to the nucleus and pseudopodia of undifferentiated cells and detected throughout the myotubes of differentiated cells Colocalizes with ACTN2, FLNC and MYOT at the Z-lines of skeletal muscle |
| Tissue Location | Expressed primarily in skeletal muscle. Detected at lower levels in heart, prostate and pancreas |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Myozenins may serve as intracellular binding proteins involved in linking Z-disk proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. This protein plays an important role in the modulation of calcineurin signaling, may play a role in myofibrillogenesis.
References
Aurino, S., et al. Acta Myol 27, 90-97 (2008) Posch, M.G., et al. Mol. Genet. Metab. 91(2):207-208(2007) Arola, A.M., et al. Mol. Genet. Metab. 90(4):435-440(2007)
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