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STMN1 (Phospho-Ser62) Antibody

Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - STMN1 (Phospho-Ser62) Antibody AP52497
    Western blot analysis of extracts from COS cells, treated with nocodazole (1ug/ml, 16hours), using STMN1 (Phospho-Ser62) antibody.
  • IHC - STMN1 (Phospho-Ser62) Antibody AP52497
    Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using STMN1 (Phospho-Ser62) antibody.
  • SPECIFICATION
  • CITATIONS
  • PROTOCOLS
  • BACKGROUND
Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC
Primary Accession P16949
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 17303 Da
Additional Information
Gene ID 3925
Other Names Stathmin, Leukemia-associated phosphoprotein p18, Metablastin, Oncoprotein 18, Op18, Phosphoprotein p19, pp19, Prosolin, Protein Pr22, pp17, STMN1, C1orf215, LAP18, OP18
Dilution WB~~1:1000
IHC~~1:50~100
Format Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Conditions-20℃
Protein Information
Name STMN1
Synonyms C1orf215, LAP18, OP18
Function Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).
Cellular Location Cytoplasm, cytoskeleton.
Tissue Location Ubiquitous. Expression is strongest in fetal and adult brain, spinal cord, and cerebellum, followed by thymus, bone marrow, testis, and fetal liver. Expression is intermediate in colon, ovary, placenta, uterus, and trachea, and is readily detected at substantially lower levels in all other tissues examined. Lowest expression is found in adult liver. Present in much greater abundance in cells from patients with acute leukemia of different subtypes than in normal peripheral blood lymphocytes, non-leukemic proliferating lymphoid cells, bone marrow cells, or cells from patients with chronic lymphoid or myeloid leukemia
Research Areas
Citations (0)

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Background

Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity).

References

Zhu X.-X.,et al.J. Biol. Chem. 264:14556-14560(1989).
Maucuer A.,et al.FEBS Lett. 264:275-278(1990).
Melhem R.F.,et al.J. Biol. Chem. 266:17747-17753(1991).
Hosoya H.,et al.Cell Struct. Funct. 21:237-243(1996).
Ota T.,et al.Nat. Genet. 36:40-45(2004).

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$ 295.00
Cat# AP52497
Size:
Quantity:
(40 western blots)
Availability: 5-7 days
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