|Application ||WB, IHC|
|Reactivity||Human, Mouse, Rat|
|Calculated MW||164470 Da|
|Other Names||Mitogen-activated protein kinase kinase kinase 1, MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1, MAP3K1, MAPKKK1, MEKK, MEKK1|
|Format||Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.|
|Synonyms||MAPKKK1, MEKK, MEKK1|
|Function||Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.|
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Provided below are standard protocols that you may find useful for product applications.
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
Schmutz J.,et al.Nature 431:268-274(2004).
Xia Y.,et al.Genes Dev. 12:3369-3381(1998).
Vinik B.S.,et al.Mamm. Genome 6:782-783(1995).
Rui H.L.,et al.J. Biol. Chem. 277:42981-42986(2002).
Wong C.K.,et al.J. Biol. Chem. 279:39366-39373(2004).
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